Difference in neuropathogenetic mechanisms in human furious and paralytic rabies

From Journal of the Neurological Sciences Volume 238, Issues 1-2 , 15 November 2005, Pages 3-10

Erawady Mitrabhakdia, , , Shanop Shuangshotib, Pongsak Wannakrairotb, Richard A. Lewisd, Keiichiro Susukic, Jiraporn Laothamatase and Thiravat Hemachudhaa
aNeurology Division, Department of Medicine, Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
bDepartment of Pathology, Chulalongkorn University Hospital, Bangkok, Thailand
cDepartment of Neurology, Dokkyo University School of Medicine, Mibu, Shimotsuga, Tochigi, Japan
dDepartment of Neurology, Wayne State University, Detroit, MI, USA
eDepartment of Radiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Abstract
Whereas paralysis is the hallmark for paralytic rabies, the precise pathological basis of paralysis is not known. It is unclear whether weakness results from involvement of anterior horn cells or of motor nerve fibers. There is also no conclusive data on the cause of the neuropathic pain which occurs at the bitten region, although it has been presumed to be related to sensory ganglionopathy. In this study, six laboratory-proven rabies patients (three paralytic and three furious) were assessed clinically and electrophysiologically. Our data suggests that peripheral nerve dysfunction, most likely demyelination, contributes to the weakness in paralytic rabies. In furious rabies, progressive focal denervation, starting at the bitten segment, was evident even in the absence of demonstrable weakness and the electrophysiologic study suggested anterior horn cell dysfunction. In two paralytic and one furious rabies patients who had severe paresthesias as a prodrome, electrophysiologic studies suggested dorsal root ganglionopathy. Postmortem studies in two paralytic and one furious rabies patients, who had local neuropathic pain, showed severe dorsal root ganglionitis. Intense inflammation of the spinal nerve roots was observed more in paralytic rabies patients. Inflammation was mainly noted in the spinal cord segment corresponding to the bite in all cases; however, central chromatolysis of the anterior horn cells could be demonstrated only in furious rabies patient. We conclude that differential sites of neural involvement and possibly different neuropathogenetic mechanisms may explain the clinical diversity in human rabies.